Minireview: transcriptional regulation in development of bone

Endocrinology. 2005 Mar;146(3):1012-7. doi: 10.1210/en.2004-1343. Epub 2004 Dec 16.


Regulation of gene expression by transcription factors is one of the major mechanisms for controlling cellular functions. Recent advances in genetic manipulation of model animals has allowed the study of the roles of various genes and their products in physiological settings and has demonstrated the importance of specific transcription factors in bone development. Three lineages of bone cells, chondrocytes, osteoblasts, and osteoclasts, develop and differentiate according to their distinct developmental programs. These cells go through multiple differentiation stages, which are often regulated by specific transcription factors. In this minireview, we will discuss selected transcription factors that have been demonstrated to critically affect bone cell development. Further study of these molecules will lead to deeper understanding in mechanisms that govern development of bone.

Publication types

  • Review

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Bone Development*
  • Cell Differentiation
  • Cell Lineage
  • Chondrocytes / cytology
  • Chondrocytes / metabolism
  • Gene Expression Regulation, Developmental*
  • Humans
  • Models, Biological
  • Neoplasm Proteins / metabolism
  • Osteoblasts / metabolism
  • Osteoclasts / metabolism
  • Sp7 Transcription Factor
  • Transcription Factors / metabolism
  • Transcription, Genetic*


  • Neoplasm Proteins
  • Sp7 Transcription Factor
  • Sp7 protein, human
  • Transcription Factors