Role of the interleukin-6 -174 G>C gene polymorphism in retinal artery occlusion

Stroke. 2005 Feb;36(2):249-52. doi: 10.1161/01.STR.0000151329.84830.37. Epub 2004 Dec 16.


Background and purpose: Proinflammatory cytokines including interleukin-6 (IL-6) are supposed to play a pivotal role in the development of atherosclerosis. A common polymorphism in the promoter of the IL-6 gene (IL-6 -174G>C) affects plasma IL-6 concentrations and has been suggested as a risk factor for cardiovascular disease. The aim of the present case-control study was to investigate the role of this polymorphism for retinal artery occlusion (RAO).

Methods: One hundred eighty-two patients with RAO and 307 control subjects were genotyped for the IL-6 -174G>C polymorphism. Genotypes were determined by fluorogenic exonuclease (TaqMan) assay.

Results: The prevalence of the CC genotype was significantly lower in patients with RAO than in control subjects (10.4% versus 19.9%; P=0.006). Homozygosity for the C allele was associated with an odds ratio of 0.50 (95% CI, 0.28 to 0.89) for RAO.

Conclusions: The CC genotype of the IL-6 -174G>C polymorphism may be associated with a protective effect against RAO.

MeSH terms

  • Aged
  • Alleles
  • Blood Pressure
  • Case-Control Studies
  • Diabetes Complications / genetics
  • Female
  • Genotype
  • Homozygote
  • Humans
  • Interleukin-6 / genetics*
  • Logistic Models
  • Male
  • Middle Aged
  • Models, Statistical
  • Odds Ratio
  • Polymorphism, Genetic*
  • Retinal Artery Occlusion / genetics*
  • Retrospective Studies


  • Interleukin-6