Identification of more than 200 glucose-responsive Arabidopsis genes none of which responds to 3-O-methylglucose or 6-deoxyglucose

Plant Mol Biol. 2004 Jul;55(4):467-77. doi: 10.1007/s11103-004-1050-0.


The response of some plant genes to glucose analogues 3-O-methylglucose (3OMG) or 6-deoxyglucose (6DOG) has been cited as evidence for metabolism-independent glucose signalling. To analyse such signalling using a genetic approach, we sought to identify Arabidopsis glucose-responsive genes which also respond to 3OMG and 6DOG in seedlings. Microarray analysis of gene expression in glucose-treated seedlings and RT-PCR analysis of glucose-treated leaf sections identified more than 200 glucose-responsive genes, but none responded to 3OMG or 6DOG. These data together with other published data on individual genes fail to identify any Arabidopsis sugar-responsive genes which also respond to 3OMG or 6DOG.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-O-Methylglucose / pharmacology*
  • Arabidopsis / drug effects
  • Arabidopsis / genetics*
  • Deoxyglucose / analogs & derivatives*
  • Deoxyglucose / pharmacology*
  • Gene Expression Regulation, Plant / drug effects*
  • Glucose / pharmacology*
  • Oligonucleotide Array Sequence Analysis / methods
  • RNA, Plant / genetics
  • RNA, Plant / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction


  • RNA, Plant
  • 3-O-Methylglucose
  • Deoxyglucose
  • Glucose
  • 6-deoxyglucose