Abstract
Recent studies in a rat model have indicated that the pathophysiological mechanisms underlying development of work-related musculoskeletal disorders (WMSDs) include widespread inflammation and subsequent fibrosis at high levels of repetition and force. A systemic inflammatory component may affect tissues not directly involved in task performance, thereby contributing to widespread and puzzling symptoms that are often characteristic of patients with WMSDs.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Proliferation
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Cumulative Trauma Disorders / metabolism
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Cumulative Trauma Disorders / physiopathology*
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Cytokines / blood
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Cytokines / immunology
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Forelimb / injuries
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Hindlimb / injuries
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Humans
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Inflammation Mediators / metabolism
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Macrophages / immunology
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Models, Animal
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Muscle, Skeletal / injuries
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Musculoskeletal Diseases / metabolism
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Musculoskeletal Diseases / physiopathology*
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Occupational Diseases / metabolism
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Occupational Diseases / physiopathology*
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Peripheral Nerve Injuries
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Rats
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Systemic Inflammatory Response Syndrome / metabolism
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Systemic Inflammatory Response Syndrome / physiopathology*
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Time Factors
Substances
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Cytokines
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Inflammation Mediators