Exercise physiology versus inactivity physiology: an essential concept for understanding lipoprotein lipase regulation

Exerc Sport Sci Rev. 2004 Oct;32(4):161-6. doi: 10.1097/00003677-200410000-00007.


Some health-related proteins such as lipoprotein lipase may be regulated by qualitatively different processes over the physical activity continuum, sometimes with very high sensitivity to inactivity. The most powerful process known to regulate lipoprotein lipase protein and activity in muscle capillaries may be initiated by inhibitory signals during physical inactivity, independent of changes in lipoprotein lipase messenger RNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cholesterol, HDL / blood
  • Exercise / physiology*
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Lipoprotein Lipase / genetics
  • Lipoprotein Lipase / metabolism*
  • Motor Activity / physiology*
  • Muscle Contraction / physiology
  • Muscle Fibers, Skeletal / physiology
  • Muscle Proteins / biosynthesis
  • Muscle, Skeletal / enzymology*
  • Muscle, Skeletal / physiology
  • RNA, Messenger / metabolism


  • Cholesterol, HDL
  • Muscle Proteins
  • RNA, Messenger
  • Lipoprotein Lipase