Treatment of pediatric chronic pain with tramadol hydrochloride: siblings with Ehlers-Danlos syndrome - Hypermobility type

Pain Res Manag. 2004 Winter;9(4):209-11. doi: 10.1155/2004/370915.


Objective: To evaluate the effectiveness of tramadol hydrochloride for the treatment of chronic pain refractory to previous treatment in two pediatric patients.

Methods: Tramadol hydrochloride was administered (50 mg/day to 150 mg/day) to two siblings with Ehlers-Danlos syndrome - Hypermobility type refractory to previous pharmacological treatments, and changes in pain intensity and physical activity were assessed.

Results: Pain intensity decreased and physical activity improved within days of starting therapy. Positive results have been maintained for 30 months.

Conclusions: Tramadol hydrochloride was a safe and effective treatment for relieving chronic pain in two pediatric patients suffering from the hypermobility type of Ehlers-Danlos syndrome. No morbidity or side effects were noted during the 30-month follow-up.

Publication types

  • Case Reports

MeSH terms

  • Analgesics, Opioid / administration & dosage*
  • Child
  • Child, Preschool
  • Chronic Disease
  • Ehlers-Danlos Syndrome / complications*
  • Humans
  • Joint Instability / etiology
  • Male
  • Pain / drug therapy*
  • Pain / etiology
  • Tramadol / administration & dosage*


  • Analgesics, Opioid
  • Tramadol