Interpretation of repeat measurement DNA evidence allowing for multiple contributors and population substructure

J M Curran; P Gill; M R Bill

doi:10.1016/j.forsciint.2004.04.077

Interpretation of repeat measurement DNA evidence allowing for multiple contributors and population substructure

Forensic Sci Int. 2005 Feb 10;148(1):47-53. doi: 10.1016/j.forsciint.2004.04.077.

Authors

J M Curran¹, P Gill, M R Bill

Affiliation

¹ Department of Statistics, University of Waikato, Private Bag 3105, Hamilton, New Zealand. curran@stats.waikato.ac.nz

PMID: 15607589
DOI: 10.1016/j.forsciint.2004.04.077

Abstract

Due to the circumstances in some forensic cases, very small amounts of DNA (<100 pg) may be obtained. This, in turn, may affect the reliability of the PCR process, and so it may be advisable to repeat the amplification process for confirmatory purposes. Gill et al. [Forensic Sci. Int. 112 (2000) 17] proposed a method for the statistical evaluation of the PCR replicate information. In this paper we formalize the method proposed by Gill et al. [Forensic Sci. Int. 112 (2000) 17], and extend it to allow for cases involving mixed stains and for population substructure.

MeSH terms

Alleles
Bayes Theorem
DNA / analysis*
DNA Fingerprinting / methods*
Genotype
Humans
Likelihood Functions*
Polymerase Chain Reaction / methods
Sample Size
Tandem Repeat Sequences*

Substances

DNA