Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

Nature. 1992 Apr 9;356(6369):494-9. doi: 10.1038/356494a0.


The gene ced-9 of the nematode Caenorhabditis elegans acts to protect cells from programmed cell death. A mutation that abnormally activates ced-9 prevents the cell deaths that occur during normal C. elegans development. Conversely, mutations that inactivate ced-9 cause cells that normally live to undergo programmed cell death; these mutations result in embryonic lethality, indicating that ced-9 function is essential for development. The ced-9 gene functions by negatively regulating the activities of other genes that are required for the process of programmed cell death.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Caenorhabditis / embryology
  • Caenorhabditis / genetics*
  • Cell Death / genetics*
  • Gene Expression Regulation
  • Genes, Lethal
  • Genotype
  • Mutation
  • Phenotype