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. 2005 Jan 1;33(Database issue):D593-7.
doi: 10.1093/nar/gki065.

IMGT, the International ImMunoGeneTics Information System

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Free PMC article

IMGT, the International ImMunoGeneTics Information System

Marie-Paule Lefranc et al. Nucleic Acids Res. .
Free PMC article

Abstract

The international ImMunoGeneTics information system (IMGT) (http://imgt.cines.fr), created in 1989, by the Laboratoire d'ImmunoGenetique Moleculaire LIGM (Universite Montpellier II and CNRS) at Montpellier, France, is a high-quality integrated knowledge resource specializing in the immunoglobulins (IGs), T cell receptors (TRs), major histocompatibility complex (MHC) of human and other vertebrates, and related proteins of the immune systems (RPI) that belong to the immunoglobulin superfamily (IgSF) and to the MHC superfamily (MhcSF). IMGT includes several sequence databases (IMGT/LIGM-DB, IMGT/PRIMER-DB, IMGT/PROTEIN-DB and IMGT/MHC-DB), one genome database (IMGT/GENE-DB) and one three-dimensional (3D) structure database (IMGT/3Dstructure-DB), Web resources comprising 8000 HTML pages (IMGT Marie-Paule page), and interactive tools. IMGT data are expertly annotated according to the rules of the IMGT Scientific chart, based on the IMGT-ONTOLOGY concepts. IMGT tools are particularly useful for the analysis of the IG and TR repertoires in normal physiological and pathological situations. IMGT is used in medical research (autoimmune diseases, infectious diseases, AIDS, leukemias, lymphomas, myelomas), veterinary research, biotechnology related to antibody engineering (phage displays, combinatorial libraries, chimeric, humanized and human antibodies), diagnostics (clonalities, detection and follow up of residual diseases) and therapeutical approaches (graft, immunotherapy and vaccinology). IMGT is freely available at http://imgt.cines.fr.

Figures

Figure 1
Figure 1
The IMGT international ImMunoGeneTics information system® (http://imgt.cines.fr). Genomics, genetics and structural components (databases and tools) are in yellow, green and blue, respectively. The IMGT Repertoire and other Web resources are not shown. Interactions in the genomics, genetics and structural approaches are represented with continuous, dotted and broken lines, respectively.

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References

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