A Structural Perspective of the Flavivirus Life Cycle

Nat Rev Microbiol. 2005 Jan;3(1):13-22. doi: 10.1038/nrmicro1067.


Dengue, Japanese encephalitis, West Nile and yellow fever belong to the Flavivirus genus, which is a member of the Flaviviridae family. They are human pathogens that cause large epidemics and tens of thousands of deaths annually in many parts of the world. The structural organization of these viruses and their associated structural proteins has provided insight into the molecular transitions that occur during the viral life cycle, such as assembly, budding, maturation and fusion. This review focuses mainly on structural studies of dengue virus.

Publication types

  • Review

MeSH terms

  • Capsid Proteins / chemistry
  • Capsid Proteins / metabolism
  • Flavivirus / chemistry*
  • Flavivirus / physiology*
  • Membrane Fusion
  • Models, Molecular
  • Protein Structure, Tertiary
  • Structure-Activity Relationship
  • Viral Envelope Proteins / chemistry
  • Viral Envelope Proteins / metabolism
  • Viral Structural Proteins / chemistry
  • Viral Structural Proteins / metabolism
  • Virion / metabolism
  • Virus Replication*


  • Capsid Proteins
  • Viral Envelope Proteins
  • Viral Structural Proteins