LPS, TLR4 and Infectious Disease Diversity

Nat Rev Microbiol. 2005 Jan;3(1):36-46. doi: 10.1038/nrmicro1068.

Abstract

Innate immune receptors recognize microorganism-specific motifs. One such receptor-ligand complex is formed between the mammalian Toll-like receptor 4 (TLR4)-MD2-CD14 complex and bacterial lipopolysaccharide (LPS). Recent research indicates that there is significant phylogenetic and individual diversity in TLR4-mediated responses. In addition, the diversity of LPS structures and the differential recognition of these structures by TLR4 have been associated with several bacterial diseases. This review will examine the hypothesis that the variability of bacterial ligands such as LPS and their innate immune receptors is an important factor in determining the outcome of infectious disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, Surface / metabolism
  • Bacterial Infections / immunology
  • Bacterial Infections / metabolism*
  • Bacterial Infections / pathology
  • Carrier Proteins / metabolism
  • Disease Progression
  • Disease Susceptibility
  • Humans
  • Immunity, Innate
  • Lipid A / chemistry
  • Lipid A / metabolism
  • Lipopolysaccharide Receptors / metabolism
  • Lipopolysaccharides / chemistry
  • Lipopolysaccharides / metabolism*
  • Lymphocyte Antigen 96
  • Membrane Glycoproteins / chemistry
  • Membrane Glycoproteins / metabolism*
  • Molecular Structure
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction
  • Species Specificity
  • Toll-Like Receptor 4
  • Toll-Like Receptors

Substances

  • Antigens, Surface
  • Carrier Proteins
  • LY96 protein, human
  • Lipid A
  • Lipopolysaccharide Receptors
  • Lipopolysaccharides
  • Lymphocyte Antigen 96
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • TLR4 protein, human
  • Toll-Like Receptor 4
  • Toll-Like Receptors