Induction of antigen cross-presentation by Toll-like receptors

Springer Semin Immunopathol. 2005 Jan;26(3):247-55. doi: 10.1007/s00281-004-0174-2. Epub 2004 Oct 14.


Cross-presentation is the pathway by which exogenous antigens are routed for presentation on MHC class I for activation of CD8(+) T cells. This pathway is important for the development of CD8(+) cytotoxic T lymphocyte responses against tumors and infectious pathogens that do not directly infect APC. We review studies showing that certain Toll-like receptors mediate cross-presentation by dendritic cells, initiating cytosolic processing of antigen after inducing dendritic cell maturation. The implications of these studies for understanding CD8(+) T cell activation and implementing novel vaccine strategies is considered.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • CD8-Positive T-Lymphocytes / immunology
  • Cell Differentiation
  • Cytosol / immunology
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology
  • Histocompatibility Antigens Class I / metabolism
  • Histocompatibility Antigens Class II / metabolism
  • Humans
  • Ligands
  • Membrane Glycoproteins / immunology*
  • Mice
  • Receptors, Cell Surface / immunology*
  • Toll-Like Receptors


  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Ligands
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors