Abstract
Biologically active, therapeutically useful, DNA binding natural products continue to reveal new paradigms for sequence-selective recognition, to enlist beautiful mechanisms of in situ activation for DNA modification, to define new therapeutic targets, to exploit new mechanisms to achieve cellular selectivity, and to provide a rich source of new drugs. These attributes arise in compact structures of complex integrated function.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antineoplastic Agents / metabolism*
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Antineoplastic Agents / pharmacology
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DNA / chemistry
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DNA / drug effects
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DNA / metabolism*
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Humans
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Models, Molecular
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Molecular Conformation
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Protein Binding / drug effects
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Stereoisomerism
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Structure-Activity Relationship
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Substrate Specificity
Substances
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Antineoplastic Agents
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DNA