Relationship between anxiety and thyroid function in patients with panic disorder

Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jan;29(1):77-81. doi: 10.1016/j.pnpbp.2004.10.008.


The aim of this study was to investigate correlations between thyroid function and severity of anxiety or panic attacks in patients with panic disorder. The authors examined 66 out-patients with panic disorder (medicated, n=41; non-medicated, n=25), and measured their free thriiodothyronine (T3), free thyroxine (T4) and thyroid-stimulating hormone (TSH) levels. Significant correlations between the thyroid hormone levels and clinical features were observed in the non-medicated patients. The more severe current panic attacks were, the higher the TSH levels were. In addition, severity of anxiety correlated negatively with free T4 levels. In this study, we discuss relationship between thyroid function and the clinical severity or features of panic disorder.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Agoraphobia / blood
  • Agoraphobia / psychology
  • Antidepressive Agents / adverse effects
  • Antidepressive Agents / therapeutic use
  • Anxiety / physiopathology*
  • Anxiety / psychology*
  • Autonomic Nervous System / physiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Panic Disorder / drug therapy
  • Panic Disorder / physiopathology*
  • Panic Disorder / psychology*
  • Psychiatric Status Rating Scales
  • Thyroid Function Tests*
  • Thyroid Hormones / blood


  • Antidepressive Agents
  • Thyroid Hormones