Nucleolus in the spotlight

Cell Cycle. 2005 Jan;4(1):106-8. doi: 10.4161/cc.4.1.1355. Epub 2005 Jan 10.

Abstract

The recent contributions on chromatid segregation at the metaphase/anaphase transition demonstrate two distinct pathways in budding yeast. While segregation of most of the genome is a direct consequence of cohesin cleavage by separase, rDNA segregation requires a novel pathway involving Cdc14 phosphatase activation. This activation induces targeting of condensin to rDNA which in association with Aurora B kinase modulates rDNA compaction during anaphase. The resolution of rDNA sequences occurs after this step.

Publication types

  • Review

MeSH terms

  • Anaphase / physiology
  • Aurora Kinases
  • Cell Cycle Proteins / physiology
  • Cell Division / physiology*
  • Cell Nucleolus / physiology*
  • Chromatids / genetics
  • Chromatids / physiology*
  • Chromosomal Proteins, Non-Histone
  • DNA, Ribosomal / genetics
  • DNA, Ribosomal / physiology
  • Enzyme Activation
  • Fungal Proteins / physiology
  • Nuclear Proteins / physiology
  • Protein Tyrosine Phosphatases / physiology
  • Protein-Serine-Threonine Kinases / metabolism
  • Saccharomyces cerevisiae / cytology*
  • Saccharomyces cerevisiae / physiology
  • Saccharomyces cerevisiae Proteins / physiology
  • Transcription, Genetic

Substances

  • CDC14 protein, S cerevisiae
  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • DNA, Ribosomal
  • Fungal Proteins
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins
  • cohesins
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases
  • Protein Tyrosine Phosphatases