High risk of recurrent venous thromboembolism in men

J Thromb Haemost. 2004 Dec;2(12):2152-5. doi: 10.1111/j.1538-7836.2004.01050.x.


Background: We have analyzed the influence of gender on risk of recurrence after a first episode of venous thromboembolism (VTE).

Methods: The Cambridge Venous Thromboembolism Study (CVTE) is a single-center study of a cohort of unselected patients with a first episode of objectively proven VTE.

Results: Recurrence rates were significantly higher in men compared with women [log rank chi2=11.82; hazard ratio (HR) 2.66; 95% confidence interval (CI) 1.49, 4,77; P=0.0006]. The cumulative recurrence rate at 2 years was 19.2% in men and 7.7% in women. There was no evidence of a difference in recurrence between men with or without thrombophilia (log rank chi2=0.03; HR 1.08; 95% CI 0.49, 2.37; P=0.855). The high recurrence rate in men compared with women was still observed when only patients with idiopathic VTE were analyzed (log rank chi2=4.38; HR 2.31; 95% CI 1.027, 5.20; P=0.0363). The recurrence risk was highest in men with a first idiopathic event at 25.7% compared with 11.7% for women in the same category.

Conclusion: The risk of recurrent VTE is higher in men than in women.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Estrogens / metabolism
  • Female
  • Humans
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Recurrence
  • Risk
  • Risk Factors
  • Sex Factors
  • Thromboembolism / diagnosis*
  • Thromboembolism / pathology*
  • Thrombophilia / complications
  • Time Factors
  • Venous Thrombosis / diagnosis*
  • Venous Thrombosis / pathology*


  • Estrogens