Centrosomal amplification and spindle multipolarity in cancer cells

Semin Cancer Biol. 2005 Feb;15(1):25-32. doi: 10.1016/j.semcancer.2004.09.003.


Recent developments have highlighted the important role centrosomal defects play in the cellular changes associated with tumorigenesis. This article reviews recent developments addressing the impact of numerical centrosomal amplification on chromosomal segregational defects in the cancer cell. Probably, the most significant is the change to the structure of the spindle that leads to increased numbers of spindle poles and abnormal partitioning of the chromosomes in mitosis. I address how centrosomal changes are initiated and how they may lead to spindle multipolarity.

Publication types

  • Review

MeSH terms

  • Centrosome / physiology*
  • Cytokinesis*
  • Forecasting
  • Humans
  • Microtubule-Associated Proteins / metabolism*
  • Neoplasms / genetics*
  • Spindle Apparatus / physiology*


  • Microtubule-Associated Proteins