Multiple myeloma and contrast media

Radiology. 1992 May;183(2):519-21. doi: 10.1148/radiology.183.2.1561361.


Contrast media administered intravenously are still thought by many to be a major cause of acute renal failure (ARF) in myeloma patients. Recently, several authors found that the predominant risk factors of ARF in myeloma patients are hypercalcemia, dehydration, infection, and Bence Jones proteinuria rather than contrast media. In a review of seven retrospective studies of myeloma patients receiving contrast media, 476 patients were noted to have undergone 568 contrast media studies, with an ARF prevalence of 0.6%-1.25%. One large series showed the incidence of ARF after administration of contrast media to be 0.15% in the general population. Although the administration of contrast media to myeloma patients is not totally risk free, it may be performed if the clinical need arises and the patient is well hydrated.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / blood
  • Acute Kidney Injury / epidemiology
  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / urine
  • Bence Jones Protein / urine*
  • Contrast Media / administration & dosage
  • Contrast Media / adverse effects*
  • Creatinine / blood
  • Dehydration / complications
  • Humans
  • Injections, Intravenous
  • Multiple Myeloma / complications*
  • Urography / adverse effects*


  • Contrast Media
  • Bence Jones Protein
  • Creatinine