An overview of clinical spectrum and heterogeneity of spondyloarthropathies

Rheum Dis Clin North Am. 1992 Feb;18(1):1-10.

Abstract

Ankylosing spondylitis and related spondyloarthropathies form a family of rheumatic diseases that are characterized by inflammatory peripheral and axial arthritis, with predilection for sacroiliitis, and a remarkably strong association with a genetic marker, HLA-B27. The association with B27 has provided a great impetus to the epidemiologic studies of spondyloarthropathies and also helped broaden the clinical spectrum of these diseases. There are at least six subtypes of B27, and the x-ray crystallographic structure of the common B27 subtype (B*2705) is now known. Endogenous peptides bound in the B27 antigen-binding cleft have been isolated and all seem to be nonamers (i.e., nine amino acids long).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Continental Population Groups
  • HLA-B27 Antigen / classification
  • Humans
  • Spinal Diseases* / genetics
  • Spinal Diseases* / physiopathology
  • Spondylitis, Ankylosing / genetics
  • Spondylitis, Ankylosing / physiopathology

Substances

  • HLA-B27 Antigen