Ginger lowers blood pressure through blockade of voltage-dependent calcium channels

J Cardiovasc Pharmacol. 2005 Jan;45(1):74-80. doi: 10.1097/00005344-200501000-00013.

Abstract

Ginger (Zingiber officinale Roscoe), a well-known spice plant, has been used traditionally in a wide variety of ailments including hypertension. We report here the cardiovascular effects of ginger under controlled experimental conditions. The crude extract of ginger (Zo.Cr) induced a dose-dependent (0.3-3 mg/kg) fall in the arterial blood pressure of anesthetized rats. In guinea pig paired atria, Zo.Cr exhibited a cardiodepressant activity on the rate and force of spontaneous contractions. In rabbit thoracic aorta preparation, Zo.Cr relaxed the phenylephrine-induced vascular contraction at a dose 10 times higher than that required against K (80 mM)-induced contraction. Ca2+ channel-blocking (CCB) activity was confirmed when Zo.Cr shifted the Ca2+ dose-response curves to the right similar to the effect of verapamil. It also inhibited the phenylephrine (1 microM) control peaks in normal-Ca2+ and Ca2+-free solution, indicating that it acts at both the membrane-bound and the intracellular Ca2+ channels. When tested in endothelium-intact rat aorta, it again relaxed the K-induced contraction at a dose 14 times less than that required for relaxing the PE-induced contraction. The vasodilator effect of Zo.Cr was endothelium-independent because it was not blocked by L-NAME (0.1 mM) or atropine (1 microM) and also was reproduced in the endothelium-denuded preparations at the same dose range. These data indicate that the blood pressure-lowering effect of ginger is mediated through blockade of voltage-dependent calcium channels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antihypertensive Agents / pharmacology*
  • Aorta, Thoracic / drug effects
  • Aorta, Thoracic / physiology
  • Blood Pressure / drug effects*
  • Calcium Channel Blockers / pharmacology*
  • Dose-Response Relationship, Drug
  • Female
  • Ginger*
  • Guinea Pigs
  • Heart Atria / drug effects
  • In Vitro Techniques
  • Male
  • Myocardial Contraction / drug effects
  • Plant Extracts / pharmacology
  • Rabbits
  • Rats
  • Rats, Sprague-Dawley
  • Rhizome
  • Vasoconstriction / drug effects
  • Vasodilation / drug effects

Substances

  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Plant Extracts