Peripheral stents or endografts in specific arterial segments are exposed to extreme mechanical stress. Despite high rates of primary technical success, mechanical bending due to knee joint flexion can limit long-term patency of stents or endografts in the popliteal artery or the femoropopliteal segment. Every stent or endograft responds differently to bending during knee joint flexion, which can be revealed only by functional investigation. Mechanical bending has to be considered in future studies to assess the influence of differences in stent design, material, or postinterventional drug treatment on the long-term patency of endoprostheses in the femoropopliteal segment. To demonstrate the concept of biomechanical incompatibility, we present several illustrations of different stent designs placed in the popliteal artery.