Down-regulation of DNA polymerases kappa, eta, iota, and zeta in human lung, stomach, and colorectal cancers

Cancer Lett. 2005 Jan 20;217(2):139-47. doi: 10.1016/j.canlet.2004.07.021.

Abstract

Human DNA polymerases kappa, eta, iota, and zeta are responsible for the translesion DNA synthesis. Numerous in vitro studies indicated that these enzymes may contribute to DNA lesion-triggered and spontaneous mutation. We measured the transcripts of these 4 enzymes in 131 self-paired cancerous and non-tumor samples, including 23 lung cancers, 49 stomach cancers, and 59 colorectal cancers. Our results indicated that, except pol eta in colorectal cancers, these enzymes are all significantly down-regulated in human lung, stomach, and colorectal cancers, suggesting that these enzymes are probably not closely associated with the elevated mutations in human cancer.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colorectal Neoplasms / enzymology*
  • DNA-Directed DNA Polymerase / metabolism*
  • Down-Regulation
  • Female
  • Humans
  • Lung Neoplasms / enzymology*
  • Male
  • Reverse Transcriptase Polymerase Chain Reaction
  • Stomach Neoplasms / enzymology*

Substances

  • DNA-Directed DNA Polymerase