Subfulminant liver failure associated with quetiapine

Eur J Gastroenterol Hepatol. 2004 Nov;16(12):1415-8. doi: 10.1097/00042737-200412000-00029.


We report the clinical history of a patient with drug induced liver injury due to quetiapine who ultimately developed subfulminant hepatic failure and died. The clinical presentation, laboratory data, as well as liver histopathology were supportive of the putative diagnosis of drug induced liver injury. To our knowledge, this is the first report of the important association between quetiapine and drug induced liver injury.

Publication types

  • Case Reports

MeSH terms

  • Antipsychotic Agents / adverse effects*
  • Bipolar Disorder / drug therapy
  • Dibenzothiazepines / adverse effects*
  • Fatal Outcome
  • Female
  • Humans
  • Liver Failure / chemically induced*
  • Liver Failure / pathology
  • Middle Aged
  • Quetiapine Fumarate


  • Antipsychotic Agents
  • Dibenzothiazepines
  • Quetiapine Fumarate