Gas6, warfarin, and kidney diseases

Clin Exp Nephrol. 2004 Dec;8(4):304-9. doi: 10.1007/s10157-004-0305-z.

Abstract

The product of growth arrest-specific gene 6 (Gas6) is a unique vitamin K-dependent autocrine growth factor for mesangial cells, and warfarin inhibits mesangial cell proliferation by interfering with the activation process of Gas6. A recent series of studies has revealed the in vivo roles of Gas6 and its receptor Axl in the progression of acute and chronic glomerulonephritis, diabetic nephropathy, chronic allograft rejection, and human kidney diseases. This review summarizes these studies and discusses the possible interventions targeting the Gas6/Axl pathway to prevent the progression of kidney diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism
  • Diabetic Nephropathies / metabolism
  • Glomerular Mesangium / cytology
  • Glomerular Mesangium / metabolism
  • Glomerulonephritis / metabolism
  • Graft Rejection / metabolism
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Kidney Diseases / metabolism*
  • Kidney Diseases / therapy
  • Mice
  • Mice, Knockout
  • STAT3 Transcription Factor
  • Signal Transduction / physiology
  • Trans-Activators / metabolism
  • Vitamin K / metabolism
  • Warfarin / metabolism*

Substances

  • DNA-Binding Proteins
  • Intercellular Signaling Peptides and Proteins
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • Stat3 protein, mouse
  • Trans-Activators
  • growth arrest-specific protein 6
  • Vitamin K
  • Warfarin