Antidiabetic effects of extracts from Psidium guajava

J Ethnopharmacol. 2005 Jan 15;96(3):411-5. doi: 10.1016/j.jep.2004.09.041.


During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on Lepr(db)/Lepr(db) mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10mg/kg in both 1- and 3-month-old Lepr(db)/Lepr(db) mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated Lepr(db)/Lepr(db) mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Disease Models, Animal
  • Fatty Liver / complications
  • Fatty Liver / drug therapy
  • Fatty Liver / pathology
  • Female
  • Hypoglycemic Agents / therapeutic use*
  • Injections, Intraperitoneal
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Phytotherapy*
  • Plant Extracts / chemistry
  • Plant Extracts / therapeutic use
  • Plant Leaves / chemistry
  • Psidium*


  • Hypoglycemic Agents
  • Plant Extracts