Implementing large-scale ENU mutagenesis screens in North America

Genetica. 2004 Sep;122(1):51-64. doi: 10.1007/s10709-004-1436-6.

Abstract

A step towards annotating the mouse genome is to use forward genetics in phenotype-driven screens to saturate the genome with mutations. The purpose of this article is to highlight the new projects in North America that are focused on isolating mouse mutations after ENU mutagenesis and phenotype screening.

Publication types

  • Review

MeSH terms

  • Animals
  • Chromosome Mapping*
  • Disease Models, Animal
  • Ethylnitrosourea
  • Female
  • Male
  • Mice / genetics*
  • Mutation*
  • National Institutes of Health (U.S.)
  • Nervous System Diseases / genetics
  • Phenotype
  • United States

Substances

  • Ethylnitrosourea