Novel cytotoxic thiodiketopiperazine derivatives from a Tilachlidium sp

J Nat Prod. 2004 Dec;67(12):2090-2. doi: 10.1021/np030326w.

Abstract

Three novel thiodiketopiperazine derivatives, T988 A, B, and C (1-3), were isolated from a Tilachlidium sp. Their structures were elucidated by spectroscopic analyses using various 1D and 2D NMR techniques. All the compounds showed potent cytotoxicity against cultured P388 leukemia cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • Fungi / chemistry*
  • Leukemia P388
  • Mice
  • Molecular Structure
  • New Zealand
  • Nuclear Magnetic Resonance, Biomolecular
  • Piperazines / chemistry
  • Piperazines / isolation & purification*
  • Piperazines / pharmacology
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Piperazines
  • T988 A compound
  • T988 B compound
  • T988 C compound