Abstract
Three novel thiodiketopiperazine derivatives, T988 A, B, and C (1-3), were isolated from a Tilachlidium sp. Their structures were elucidated by spectroscopic analyses using various 1D and 2D NMR techniques. All the compounds showed potent cytotoxicity against cultured P388 leukemia cells.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / isolation & purification*
-
Antineoplastic Agents / pharmacology
-
Drug Screening Assays, Antitumor
-
Fungi / chemistry*
-
Leukemia P388
-
Mice
-
Molecular Structure
-
New Zealand
-
Nuclear Magnetic Resonance, Biomolecular
-
Piperazines / chemistry
-
Piperazines / isolation & purification*
-
Piperazines / pharmacology
-
Tumor Cells, Cultured
Substances
-
Antineoplastic Agents
-
Piperazines
-
T988 A compound
-
T988 B compound
-
T988 C compound