The Teichoic Acid (C-polysaccharide) Synthesized by Streptococcus Pneumoniae Serotype 5 Has a Specific Structure

Carbohydr Res. 2005 Jan 17;340(1):91-6. doi: 10.1016/j.carres.2004.10.021.


The teichoic acid synthesized by Streptococcus pneumoniae serotype 5, also known as pneumococcal common antigen (C-polysaccharide), was purified. On the basis of compositional analysis, HPAEC-PAD analysis, MALDI-TOF mass spectrometry and NMR spectroscopy, made on the native polysaccharide and on the dephosphorylated repeating unit, the following structure is proposed: [structure: see text]. This C-polysaccharide (C-PS), differs from those previously described by the replacement of Glc by Gal in its repeating unit structure.

MeSH terms

  • Carbohydrate Sequence
  • Hydrofluoric Acid / pharmacology
  • Hydrolysis / drug effects
  • Magnetic Resonance Spectroscopy
  • Molecular Sequence Data
  • Serotyping
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Streptococcus pneumoniae / chemistry
  • Streptococcus pneumoniae / classification*
  • Streptococcus pneumoniae / metabolism*
  • Teichoic Acids / chemistry*
  • Teichoic Acids / isolation & purification


  • Teichoic Acids
  • Hydrofluoric Acid