Solitary fibrous tumors of the pleura: surgical outcome and clinical course

Ann Thorac Surg. 2005 Jan;79(1):303-7. doi: 10.1016/j.athoracsur.2004.07.013.


Background: The aim of this study was to define more precisely the surgical outcome and clinical course of solitary fibrous tumors of the pleura.

Methods: We conducted a retrospective review of the clinical records of patients who had undergone surgical resection for benign and malignant solitary fibrous tumors of the pleura during a 10-year period (1993 to 2003).

Results: Sixty-three patients were enrolled in the study (men, 29; women, 34; mean age, 49.6 years). Thirty-six patients (57.1%) were symptomatic at the time of diagnosis. Resection was performed through a thoracotomy (n = 37), by means of video-assisted thoracoscopy (n = 22), or through a sternotomy (n = 4). Mass excision only was performed in 34 cases, and en bloc excision including adjacent structures was performed in 29 cases. Forty-four cases (69.8%) were benign and 19 (30.2%) were malignant. Local recurrences occurred in three cases and distant metastases in eight. Recurrences occurred only in malignancy. Symptomatic presentation and the impression of a nonpleural tumor by imaging study were found to be related to a malignant pathologic diagnosis. The radiologic impression of solitary fibrous tumors of the pleura was also related to mass excision only.

Conclusions: For malignant cases, complete surgical resection may be insufficient for the cure. Therefore, further study should be performed to define the role of preoperative and postoperative systemic treatment.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy, Fine-Needle
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Incidental Findings
  • Life Tables
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Neoplasms, Fibrous Tissue / diagnostic imaging
  • Neoplasms, Fibrous Tissue / mortality
  • Neoplasms, Fibrous Tissue / pathology
  • Neoplasms, Fibrous Tissue / secondary
  • Neoplasms, Fibrous Tissue / surgery*
  • Pleural Neoplasms / diagnostic imaging
  • Pleural Neoplasms / mortality
  • Pleural Neoplasms / pathology
  • Pleural Neoplasms / surgery*
  • Retrospective Studies
  • Sternum / surgery
  • Thoracic Surgery, Video-Assisted* / statistics & numerical data
  • Thoracotomy* / statistics & numerical data
  • Tomography, X-Ray Computed
  • Treatment Outcome