Age and the prevalence of bleeding disorders in women with menorrhagia

Obstet Gynecol. 2005 Jan;105(1):61-6. doi: 10.1097/01.AOG.0000148889.15061.fb.


Objective: A study was conducted to evaluate the frequency and types of hemostatic defects occurring in adolescent and perimenopausal-age women diagnosed with menorrhagia.

Methods: A total of 115 women with a physician diagnosis of menorrhagia, including 25 adolescent women, 25 perimenopausal-age women, and 65 women between the ages of 20 and 44, underwent comprehensive hemostatic testing for possible bleeding disorders. Frequencies of bleeding disorders were calculated and compared.

Results: Forty-seven percent of women were found to have hemostatic abnormalities, including platelet dysfunction, von Willebrand's disease, and coagulation factor deficiencies. Adolescents and perimenopausal-age women with menorrhagia were just as likely to have hemostatic abnormalities as were women aged 20 to 44.

Conclusion: These results demonstrate that underlying bleeding disorders are frequently found in adolescent, postadolescent reproductive age, and perimenopausal-age women presenting with menorrhagia and suggest that women with menorrhagia should be considered for further hemostatic evaluation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Blood Platelets / physiology
  • Female
  • Hemorrhagic Disorders / complications*
  • Hemorrhagic Disorders / diagnosis
  • Humans
  • Menorrhagia / blood
  • Menorrhagia / complications*
  • Middle Aged
  • Platelet Aggregation
  • von Willebrand Factor / analysis


  • von Willebrand Factor