Control of viral rebound through therapeutic immunization with DermaVir

AIDS. 2005 Jan 3;19(1):35-43. doi: 10.1097/00002030-200501030-00004.


Objective: To reconstitute immune responses capable of eliminating infected cells and suppressing viral load during chronic retroviral infection.

Design: : A topical, DNA-based therapeutic immunization (DermaVir) was designed to express most of the regulatory and structural viral genes in dendritic cells.

Methods: DermaVir alone and in combination with antiretroviral drugs was tested in chronically SIV-infected macaques.

Results: DermaVir provided virological, immunological and clinical benefit for SIV-infected macaques during chronic infection and AIDS. In combination with antiretroviral drugs, DermaVir augmented SIV-specific T-cell responses and enhanced control of viral load rebound during treatment interruptions.

Conclusions: The results indicate the feasibility of therapeutic immunization even in immune compromised hosts, and suggest that DermaVir can complement antiretroviral drugs to sustain suppression of HIV-1 replication.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS Vaccines / adverse effects
  • AIDS Vaccines / therapeutic use*
  • Acquired Immunodeficiency Syndrome / drug therapy
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / virology
  • Animals
  • Antiretroviral Therapy, Highly Active / methods*
  • CD4-Positive T-Lymphocytes / immunology
  • Chronic Disease
  • Cohort Studies
  • Dendritic Cells / immunology
  • Drug Therapy, Combination
  • Female
  • Immunization / methods
  • Lymphocyte Count
  • Macaca
  • Male
  • RNA, Viral / analysis
  • Simian Acquired Immunodeficiency Syndrome / drug therapy*
  • Simian Acquired Immunodeficiency Syndrome / immunology
  • Simian Acquired Immunodeficiency Syndrome / virology
  • Simian Immunodeficiency Virus / physiology
  • Swine
  • Viral Load / methods
  • Virus Replication / immunology


  • AIDS Vaccines
  • DermaVir
  • RNA, Viral