Evolution of Microglial Activation in Patients After Ischemic Stroke: A [11C](R)-PK11195 PET Study

Neuroimage. 2005 Jan 15;24(2):591-5. doi: 10.1016/j.neuroimage.2004.09.034. Epub 2004 Nov 18.

Abstract

We obtained [11C](R)-PK11195 PET scans in six patients at different time points between 3 and 150 days after onset of ischemic stroke in order to measure the time course of microglial activation. Increased [11C](R)-PK11195 binding around the lesion was observed as early as 3 days. Scans at later time points showed ongoing changes in the distribution of the [11C](R)-PK11195 signal, involving the area of the primary lesion and areas distant from the primary lesion site. Our data suggest that [11C](R)-PK11195 PET can be used to investigate both the primary lesion and remote pathological changes following Wallerian degeneration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brain Ischemia / diagnostic imaging*
  • Brain Ischemia / pathology
  • Brain Ischemia / physiopathology
  • Brain Mapping / methods
  • Brain Stem / blood supply
  • Carbon Radioisotopes*
  • Cerebral Arteries
  • Humans
  • Isoquinolines*
  • Microglia / physiology*
  • Middle Aged
  • Positron-Emission Tomography / methods

Substances

  • Carbon Radioisotopes
  • Isoquinolines
  • PK 11195