Thrombin-antithrombin III complexes in type II diabetes mellitus

J Diabetes Complications. Jan-Mar 1992;6(1):7-11. doi: 10.1016/1056-8727(92)90042-j.


Several studies suggest that diabetes is associated with a hypercoagulable state. Therefore determination of thrombin-antithrombin complex (TAT) could represent a sensitive parameter for specific detection of a latent activation of the clotting system. The present study documents increased plasma TAT in a heterogeneous group of non-insulin-dependent diabetic patients. The finding of increased TAT levels both in diabetic patients with vascular complications and in vascular disease patients without diabetes suggests a relationship between existing vascular disease and the hemostatic mechanism that produces augmented thrombin activity. In acute vascular occlusions the presence of diabetes seems to increase activation of the coagulative system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Antithrombin III / isolation & purification
  • Antithrombin III / metabolism*
  • Cerebrovascular Disorders / blood
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetic Angiopathies / blood*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Reference Values
  • Regression Analysis
  • Thrombin / isolation & purification
  • Thrombin / metabolism*


  • Antithrombin III
  • Thrombin