Decreased lateral geniculate nucleus activation in retrogeniculate hemianopia demonstrated by functional magnetic resonance imaging at 4 Tesla
- PMID: 15627821
- DOI: 10.1159/000081776
Decreased lateral geniculate nucleus activation in retrogeniculate hemianopia demonstrated by functional magnetic resonance imaging at 4 Tesla
Abstract
Functional magnetic resonance imaging (fMRI) can detect lateral geniculate nucleus (LGN) activation. We studied LGN function in 5 patients with retrogeniculate homonymous hemianopia using fMRI at 4.0 Tesla during binocular visual stimulation. Decreased activation of visual cortex and LGN on the side of the lesion was observed in all 5 patients. These findings suggest that retrogeniculate lesions are associated with decreased activation of the LGN, due to retrograde degeneration or a functional decrease caused by decreased feedback from ipsilateral visual cortex.
Copyright (c) 2005 S. Karger AG, Basel.
Similar articles
-
Decreased gray matter concentration in the lateral geniculate nuclei in human amblyopes.Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1432-8. doi: 10.1167/iovs.09-3931. Epub 2009 Oct 29. Invest Ophthalmol Vis Sci. 2010. PMID: 19875650
-
Recovery from optic neuritis: an ROI-based analysis of LGN and visual cortical areas.Brain. 2007 May;130(Pt 5):1244-53. doi: 10.1093/brain/awm045. Brain. 2007. PMID: 17472983
-
Functional magnetic resonance imaging of lateral geniculate nucleus at 1.5 tesla.J Neuroophthalmol. 2000 Dec;20(4):285-7. J Neuroophthalmol. 2000. PMID: 11130759
-
[Lesions of the posterior visual pathways: clinical presentation and mechanisms of functional restoration].Klin Monbl Augenheilkd. 1988 May;192(5):529-31. doi: 10.1055/s-2008-1050173. Klin Monbl Augenheilkd. 1988. PMID: 3043101 Review. French.
-
[Hemianopsias in cortical and subcortical lesions of the visual system: what is the difference?].Klin Monbl Augenheilkd. 1988 May;192(5):521-4. doi: 10.1055/s-2008-1050171. Klin Monbl Augenheilkd. 1988. PMID: 3043100 Review. German.
Cited by
-
Survival of retinal ganglion cells after damage to the occipital lobe in humans is activity dependent.Proc Biol Sci. 2019 Feb 27;286(1897):20182733. doi: 10.1098/rspb.2018.2733. Proc Biol Sci. 2019. PMID: 30963844 Free PMC article.
-
Retinal Ganglion Cell Atrophy in Homonymous Hemianopia due to Acquired Occipital Lesions Observed Using Cirrus High-Definition-OCT.J Ophthalmol. 2016;2016:2394957. doi: 10.1155/2016/2394957. Epub 2016 May 4. J Ophthalmol. 2016. PMID: 27274865 Free PMC article.
-
Sectoral analysis of the retinal nerve fiber layer thinning and its association with visual field loss in homonymous hemianopia caused by post-geniculate lesions using spectral-domain optical coherence tomography.Graefes Arch Clin Exp Ophthalmol. 2016 Apr;254(4):745-56. doi: 10.1007/s00417-015-3181-1. Epub 2015 Oct 7. Graefes Arch Clin Exp Ophthalmol. 2016. PMID: 26446718 Free PMC article.
-
Reduced retinal ganglion cell complex thickness in patients with posterior cerebral artery infarction detected using spectral-domain optical coherence tomography.Jpn J Ophthalmol. 2012 Sep;56(5):502-10. doi: 10.1007/s10384-012-0146-3. Epub 2012 Jun 9. Jpn J Ophthalmol. 2012. PMID: 22684619
-
Noninvasive measurement of the cerebral blood flow response in human lateral geniculate nucleus with arterial spin labeling fMRI.Hum Brain Mapp. 2008 Oct;29(10):1207-14. doi: 10.1002/hbm.20459. Hum Brain Mapp. 2008. PMID: 17712783 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
