Inter-eye difference in diabetic macular edema after unilateral intravitreal injection of triamcinolone acetonide

Am J Ophthalmol. 2004 Dec;138(6):970-7. doi: 10.1016/j.ajo.2004.07.007.


Purpose: To report on visual outcome of patients receiving intravitreal triamcinolone acetonide for treatment of diffuse diabetic macular edema.

Design: Prospective, comparative clinical interventional study.

Setting: Institutional. patient population: The study included 25 consecutive patients (50 eyes) with bilateral diabetic macular edema. Intervention procedure: Unilateral intravitreal injection of about 20 mg triamcinolone acetonide into the eye (study group) more severely affected by diabetic maculopathy. The contralateral eyes served as control group. Mean follow-up was 7.1 +/- 4.1 months.

Main outcome measure: Visual acuity, intraocular pressure.

Results: In the study group, visual acuity increased significantly (P < or = .001) by 3.0 +/- 2.6 Snellen lines to a peak at two to six months after the injection, and decreased significantly (P = .001) towards the end of follow up. At the end of follow-up, visual acuity was higher, not significantly (P = .18) higher, than at baseline. An increase in visual acuity was found in 23 eyes (92%). In the control group, differences between visual acuity at baseline and at any of the re-examinations during follow-up were not significant (P > .10). In an intra-individual inter-eye comparison, gain in visual acuity was significantly (P < .05) higher in the injected eyes, for the measurements obtained up to four months after injection.

Conclusions: Intravitreal triamcinolone acetonide may temporarily increase visual acuity in eyes with diabetic macular edema.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Diabetic Retinopathy / drug therapy*
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / therapeutic use*
  • Humans
  • Injections
  • Intraocular Pressure
  • Macular Edema / drug therapy*
  • Middle Aged
  • Pilot Projects
  • Prospective Studies
  • Triamcinolone Acetonide / administration & dosage
  • Triamcinolone Acetonide / therapeutic use*
  • Visual Acuity / drug effects
  • Vitreous Body


  • Glucocorticoids
  • Triamcinolone Acetonide