Diagnostic accuracy of noninvasive coronary imaging using 16-detector slice spiral computed tomography with 188 ms temporal resolution

J Am Coll Cardiol. 2005 Jan 4;45(1):123-7. doi: 10.1016/j.jacc.2004.10.050.


Objectives: The aim of our study was to evaluate the diagnostic accuracy of 16-multi-detector spiral computed tomography (MDCT) with 188 ms temporal resolution.

Background: Because of rapid technical innovations, MDCT coronary imaging has significantly improved in the last five years. Recent results indicate a high diagnostic accuracy, especially in patients with clinical suspicion of coronary artery disease (CAD).

Methods: A total of 72 consecutive patients (30 women, 42 men, age 64 +/- 10 years) scheduled for invasive coronary angiography (ICA) because of suspected CAD were additionally studied by MDCT (Sensation 16 Speed 4D, Siemens, Forchheim, Germany). Thirty-seven of 72 patients (51%) received an additional beta-blockade before MDCT because of heart rates >65 beats/min. The MDCT scans were analyzed regarding the presence of coronary artery lesions. Results were compared with ICA.

Results: All 72 scans showed diagnostic image quality (heart rate: 64.1 +/- 9.2 beats/min, calcium mass: 86 +/- 156 mg). Thirteen coronary segments were evaluated in each patient. Sixty-two of 936 (6.6%) segments showed a nondiagnostic image quality. All segments were included in the analysis. A total of 117 relevant lesions (diameter stenosis >50%) were detected using ICA, and 96 of 117 (82%) were detected by MDCT. Sensitivity, specificity, and positive and negative predictive values for the whole study group were as follows: 82%, 98%, 87%, and 97%, respectively. The correct clinical diagnosis of presence or absence of significant CAD was obtained in 65 of 72 (90%) patients. All stenoses were detected by MDCT in 52 of 72 (72%) patients.

Conclusions: Our results indicate a high diagnostic accuracy of 16-slice MDCT with improved temporal resolution.

MeSH terms

  • Adult
  • Aged
  • Coronary Disease / diagnostic imaging*
  • Coronary Stenosis / diagnostic imaging
  • Feasibility Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Sensitivity and Specificity
  • Sex Factors
  • Tomography, Spiral Computed / methods*