Spontaneous ocular squamous cell carcinoma in twin goats: pathological and biomolecular studies

J Comp Pathol. 2005 Jan;132(1):96-100. doi: 10.1016/j.jcpa.2004.06.007.


Ocular squamous cell carcinoma (OSCC) is a well-characterized tumour occurring spontaneously in cattle and other mammalian species but not previously reported in the goat. This report describes the histological features of well-differentiated OSCCs in twin goats. Biomolecular investigations led to the identification of Papillomavirus-related DNA sequences within the neoplastic ocular parenchyma of both animals, but immunohistochemical and ultrastructural studies failed to demonstrate viral particles. A putative role of Papillomavirus in the aetiology of OSCC is discussed, together with other possible causative factors.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carcinoma, Squamous Cell / etiology
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / veterinary*
  • DNA, Viral / analysis
  • Eye Neoplasms / etiology
  • Eye Neoplasms / pathology
  • Eye Neoplasms / veterinary*
  • Female
  • Goat Diseases*
  • Goats
  • Immunoenzyme Techniques / veterinary
  • Male
  • Papillomaviridae / genetics
  • Papillomaviridae / isolation & purification
  • Papillomavirus Infections / complications
  • Papillomavirus Infections / pathology
  • Papillomavirus Infections / veterinary*
  • Twins


  • DNA, Viral