Complete genome sequence of cercopithecine herpesvirus 2 (SA8) and comparison with other simplexviruses

Virology. 2005 Jan 20;331(2):429-40. doi: 10.1016/j.virol.2004.09.042.


We have obtained the complete sequence of the herpesvirus simian agent 8 (SA8; cercopithecine herpesvirus 2) a baboon simplexvirus closely related to the monkey B virus and herpes simplex virus types 1 and 2. The genome of SA8 is 150,715 bp long, with an overall G/C content of 76%, the highest among the simplexviruses sequenced so far. The sequencing has confirmed that the genomic arrangement of SA8 is similar to that of other simplexviruses: unique long and unique short regions bordered by two sets of inverted repeats. All genes identified in SA8 are homologous and collinear with those of the monkey B virus, including the lack of the RL1 open reading frame, a gene responsible for neurovirulence in human herpes simplex viruses. This latter finding supports the hypothesis that a different pathogenetic mechanism may have developed in human simplexviruses, after their divergence from monkey simplexviruses.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alphaherpesvirinae / genetics*
  • Animals
  • Base Sequence
  • Chlorocebus aethiops
  • DNA, Viral / analysis
  • Genome, Viral
  • Macaca mulatta
  • Open Reading Frames / genetics
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid
  • Simplexvirus / genetics*
  • Vero Cells
  • Viral Envelope Proteins / genetics*
  • Viral Proteins / chemistry
  • Viral Proteins / genetics


  • DNA, Viral
  • Viral Envelope Proteins
  • Viral Proteins
  • SA8 glycoprotein B, simian herpesvirus