Promoting effect and recovery activity from physical stress of the fruit of Morus alba

Biofactors. 2004;21(1-4):267-71. doi: 10.1002/biof.552210152.


We examined the effects of the fruit of M. alba extracts on the changes of the monoamine oxidase (MAO) activities during and after the physical exercise in rat. Each activity was measured by used serotonin(5-HT) and benzylamine as substrate. Lactate dehydrogenase(LDH) activity and the concentrations of lactate in blood which were clinical indexes of physical exercise were also determined to compare with the relation of MAO activities. Those activities during and after the physical exercise have different tendency in each other enzyme. MAO-A activity was sharply decreased with stress by physical activities compared to the normal group, whereas MAO-B activity was increased for 60 minutes after exercise. All of these indexes were recovered to normal state by oral administration of extract of M. alba. These results of this study suggested M. alba may modulate the MAO activities during exercise and promote the capability of physical activities and show anti-stress effect. In general, MAO inhibitors have been used drugs for the purpose of treatment Parkinson's disease, dementia, depression. These results can apply to produce the health and functional foods that have modulating effects for these diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers
  • Brain / enzymology
  • L-Lactate Dehydrogenase / metabolism
  • Lactates / blood
  • Liver / enzymology
  • Monoamine Oxidase / metabolism
  • Morus*
  • Physical Exertion / physiology*
  • Rats
  • Serotonin / metabolism
  • Stress, Physiological / physiopathology*
  • Swimming


  • Biomarkers
  • Lactates
  • Serotonin
  • L-Lactate Dehydrogenase
  • Monoamine Oxidase