Enhancement of insulin sensitivity in adipocytes by ginger

Biofactors. 2004;22(1-4):153-6. doi: 10.1002/biof.5520220130.


Antidiabetic and hypoglycemic drugs have been reported to enhance adipocyte differentiation of 3T3-L1 preadipocytes. We previously reported that ginseng (active constituents: ginsenosides) enhanced the differentiation [1]. In this experiment, effect of some ginger group food extracts on the adipocyte differentiation was investigated using cultured mouse 3T3-L1 preadipocytes. 3T3-L1 cells were grown as monolayer cultures at 37 degrees C in DMEM supplemented by 10% FBS under the atmosphere of 5% CO(2)-95% air. Ginger extracts were found to enhance the adipocyte differentiation. Active constituent was purified and identified as gingerol. In the gingerol-treated cells, insulin-sensitive glucose uptake was increased. It is expected that ginger enhance the insulin-sensitivity, and improve chronic disease, such as diabetes.

MeSH terms

  • 3T3 Cells
  • Adipocytes / cytology
  • Adipocytes / drug effects
  • Adipocytes / physiology*
  • Animals
  • Cell Culture Techniques / methods
  • Cell Differentiation / drug effects*
  • Ginger*
  • Hypoglycemic Agents / pharmacology*
  • Insulin / pharmacology*
  • Mice
  • Plant Extracts / pharmacology*


  • Hypoglycemic Agents
  • Insulin
  • Plant Extracts