Aurora-A - a guardian of poles

Nat Rev Cancer. 2005 Jan;5(1):42-50. doi: 10.1038/nrc1526.

Abstract

The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aurora Kinases
  • Cell Cycle Proteins
  • Cell Transformation, Neoplastic
  • Humans
  • Kinetochores
  • Mitosis / physiology*
  • Neoplasms / enzymology*
  • Neoplasms / pathology
  • Protein Kinases / physiology*
  • Protein-Serine-Threonine Kinases
  • Spindle Apparatus*
  • Xenopus Proteins

Substances

  • Cell Cycle Proteins
  • Xenopus Proteins
  • Protein Kinases
  • AURKA protein, Xenopus
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases