Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 6 (1), 24-35

RNAi-mediated Pathways in the Nucleus

Affiliations
Review

RNAi-mediated Pathways in the Nucleus

Marjori A Matzke et al. Nat Rev Genet.

Abstract

RNA interference (RNAi) is an evolutionarily conserved mechanism that uses short antisense RNAs that are generated by 'dicing' dsRNA precursors to target corresponding mRNAs for cleavage. However, recent developments have revealed that there is also extensive involvement of RNAi-related processes in regulation at the genome level. dsRNA and proteins of the RNAi machinery can direct epigenetic alterations to homologous DNA sequences to induce transcriptional gene silencing or, in extreme cases, DNA elimination. Furthermore, in some organisms RNAi silences unpaired DNA regions during meiosis. These mechanisms facilitate the directed silencing of specific genomic regions.

Similar articles

See all similar articles

Cited by 278 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback