Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

J Clin Invest. 2005 Jan;115(1):118-27. doi: 10.1172/JCI19189.

Abstract

The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation / drug effects
  • Cell Movement / drug effects
  • Cells, Cultured
  • Coronary Vessels / cytology
  • Coronary Vessels / drug effects
  • Endothelial Cells / cytology*
  • Endothelial Cells / drug effects*
  • Hindlimb / blood supply
  • Hindlimb / drug effects
  • Humans
  • Ischemia / chemically induced
  • Ischemia / drug therapy*
  • Ischemia / metabolism
  • Ischemia / pathology*
  • Lymphokines
  • Mice
  • Microcirculation / drug effects
  • Myocardium / metabolism
  • Myocardium / pathology
  • Neovascularization, Physiologic / drug effects*
  • Phosphotyrosine / metabolism
  • Platelet-Derived Growth Factor / pharmacology*
  • Receptors, Platelet-Derived Growth Factor / metabolism
  • Signal Transduction
  • Stem Cells / cytology
  • Stem Cells / drug effects*

Substances

  • Lymphokines
  • Platelet-Derived Growth Factor
  • platelet-derived growth factor C
  • Phosphotyrosine
  • Receptors, Platelet-Derived Growth Factor