Imaging of macrophage-related lung diseases

Eur Radiol. 2005 Apr;15(4):727-41. doi: 10.1007/s00330-004-2554-3. Epub 2005 Jan 5.


Macrophage-related pulmonary diseases are a heterogeneous group of disorders characterized by macrophage accumulation, activation or dysfunction. These conditions include smoking-related interstitial lung diseases, metabolic disorders such as Niemann-Pick or Gaucher disease, and rare primary lung tumors. High-resolution computed tomography abnormalities include pulmonary ground-glass opacification secondary to infiltration by macrophages, centrilobular nodules or interlobular septal thickening reflecting peribronchiolar or septal macrophage accumulation, respectively, emphysema caused by macrophage dysfunction, and honeycombing following macrophage-related lung matrix remodeling.

Publication types

  • Review

MeSH terms

  • Capillaries
  • Humans
  • Lung Diseases / diagnostic imaging*
  • Lung Diseases / metabolism
  • Lung Diseases / pathology
  • Lung Diseases, Interstitial / diagnostic imaging*
  • Lung Diseases, Interstitial / pathology
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / pathology
  • Macrophages, Alveolar*
  • Pulmonary Emphysema / diagnostic imaging
  • Pulmonary Emphysema / pathology
  • Radiography
  • Smoking / pathology