[Frequent genetic deletion of detoxifying enzyme GSTM1 and GSTT1 genes in nasopharyngeal carcinoma patients in Guangxi Province, China]

Zhonghua Zhong Liu Za Zhi. 2004 Oct;26(10):598-600.
[Article in Chinese]


Objective: To study the genetic susceptibility to chemical carcinogens of nasopharyngeal carcinoma (NPC) patients in a high-risk area in Guangxi.

Methods: PCR technique was used to examine the frequency of glutathione S-transferase M1 and T1 gene deletion in a matched case-control study of 91 patients with NPC and 135 control subjects.

Results: The deletion frequency of control subjects was 47.4% (65/135) for GSTM1 and 40.7% (55/135) for GSTT1, whereas that of NPC patients was 61.5% (56/91) for GSTM1 and 59.3% (54/91) for GSTT1 with statistically significant difference between the patients and the controls (P < 0.05 and P < 0.01). Furthermore, the frequency of codeletion of both genes was also higher in NPC patients than the control with statistically significant difference (chi2 = 12.533, P = 0.002).

Conclusion: In high-risk area, nasopharyngeal carcinoma patients and local residents have high frequency of GSTM1 and/or GSTT1 gene deletion. It suggests that a genetic susceptibility to putative chemical carcinogens may be responsible for NPC clustering in the high-risk area studied.

Publication types

  • English Abstract

MeSH terms

  • Case-Control Studies
  • China
  • Gene Deletion*
  • Genetic Predisposition to Disease*
  • Glutathione Transferase / genetics*
  • Humans
  • Nasopharyngeal Neoplasms / enzymology*
  • Nasopharyngeal Neoplasms / genetics


  • glutathione S-transferase T1
  • Glutathione Transferase
  • glutathione S-transferase M1