Botulinum toxin as a treatment for blepharospasm, spasmodic torticollis and hemifacial spasm

Eur Neurol. 1992;32(2):112-7. doi: 10.1159/000116805.


Fifty-two patients affected by focal dystonia or hemifacial spasm were treated with repeated injections of botulinum toxin. A clinical improvement was observed in all patients with blepharospasm; clinical benefit had a mean duration of 10 weeks. Clinical results were less impressive, but also favorable in patients affected by spasmodic torticollis and by hemifacial spasm. In the latter, the incidence of drug-induced paresis was much higher than that observed in patients with blepharospasm, even though the doses of toxin injected were significantly lower.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blepharospasm / drug therapy*
  • Blepharospasm / etiology
  • Botulinum Toxins / administration & dosage*
  • Botulinum Toxins / adverse effects
  • Dose-Response Relationship, Drug
  • Facial Muscles* / drug effects
  • Female
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Neurologic Examination
  • Spasm / drug therapy*
  • Torticollis / drug therapy*
  • Torticollis / etiology


  • Botulinum Toxins