Variation of the polymorphic region X of the protein A gene during persistent airway infection of cystic fibrosis patients reflects two independent mechanisms of genetic change in Staphylococcus aureus

J Clin Microbiol. 2005 Jan;43(1):502-5. doi: 10.1128/JCM.43.1.502-505.2005.


Variation of the polymorphic region of the protein A gene (spa) was observed during long-term persistence of Staphylococcus aureus in the airways of 10 cystic fibrosis patients and occurred at a rate of one genetic change every 70 months. Independent mutational events were observed eight times in 142 isolates: four deletions, two duplications of repeats, and two point mutations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chronic Disease
  • Cystic Fibrosis / microbiology*
  • Electrophoresis, Gel, Pulsed-Field
  • Genetic Variation*
  • Humans
  • Mutation*
  • Polymorphism, Genetic*
  • Staphylococcal Infections / microbiology
  • Staphylococcal Protein A / chemistry
  • Staphylococcal Protein A / genetics*
  • Staphylococcus aureus / classification
  • Staphylococcus aureus / genetics*


  • Staphylococcal Protein A