Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica

Biol Pharm Bull. 2005 Jan;28(1):173-5. doi: 10.1248/bpb.28.173.

Abstract

The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated. Activity-guided fractionation of MeOH extract resulted in the isolation of ursolic acid lactone, ursolic acid, pomolic acid, 2alpha,3alpha-dihydroxyurs-12-en-28-oic acid, 3-epimaslinic acid, asiatic acid, corosolic acid, and rosmarinic acid. Antiproliferative activity of the isolated compounds against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and murine melanoma (B16F10) cells was estimated.

MeSH terms

  • Apiaceae
  • Cell Proliferation / drug effects*
  • Centella*
  • Cinnamates / chemistry
  • Cinnamates / isolation & purification
  • Cinnamates / pharmacology*
  • Depsides
  • Growth Inhibitors / chemistry
  • Growth Inhibitors / isolation & purification
  • Growth Inhibitors / pharmacology*
  • HeLa Cells
  • Humans
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Cinnamates
  • Depsides
  • Growth Inhibitors
  • Plant Extracts
  • Triterpenes
  • rosmarinic acid