Antibacterial constituents from the berries of Piper nigrum

S Venkat Reddy; Pullela V Srinivas; B Praveen; K Hara Kishore; B China Raju; U Suryanarayana Murthy; J Madhusudana Rao

doi:10.1016/j.phymed.2003.04.004

Antibacterial constituents from the berries of Piper nigrum

Phytomedicine. 2004 Nov;11(7-8):697-700. doi: 10.1016/j.phymed.2003.04.004.

Authors

S Venkat Reddy¹, Pullela V Srinivas, B Praveen, K Hara Kishore, B China Raju, U Suryanarayana Murthy, J Madhusudana Rao

Affiliation

¹ Natural Product Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India.

PMID: 15636188
DOI: 10.1016/j.phymed.2003.04.004

Abstract

Piper nigrum finds an extensive application in antibacterial preparations belonging to Ayurvedic system of medicine. A bioguided extraction and fractionation of the petroleum ether extract of the berries of P. nigrum afforded 2E, 4E, 8Z-N-isobutyleicosatrienamide (1), pellitorine (2), trachyone (3), pergumidiene (4) and isopiperolein B (5). Pergumidiene and trachyone are isolated for the first time from P. nigrum. All the isolated compounds were active against Bacillus subtilis, Bacillus sphaericus, and Staphylococcus aureus amongst Gram + ve bacteria, and Klebsiella aerogenes and Chromobacterium violaceum among Gram -ve bacterial strains.

MeSH terms

Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Bacillus / drug effects
Chromobacterium / drug effects
Enterobacter aerogenes / drug effects
Piper nigrum / chemistry*
Plant Extracts / chemistry
Plant Extracts / pharmacology
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents
Plant Extracts