Interactions among the cannabinoids in the antagonism of the abdominal constriction response in the mouse

Psychopharmacology (Berl). 1979 Mar 28;61(3):281-5. doi: 10.1007/BF00432273.

Abstract

The ability of delta 9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8 alpha, 11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E1 (PGE1) and bradykinin was tested. THC was an effective antagonist against all nociceptive agents with an ED50 in all cases between 1.0 and 2.6 mg/kg. CBN, while also effective against all nociceptive agents, was less potent than THC, with an ED50 range between 46.2 and 112.5 mg/kg. CBD in doses as high as 200 mg/kg was without effect. Using PGE1 as the nociceptive agent, 11-OH THC was equipotent to THC while 8 alpha, 11-diOH THC was inactive. Naloxone, while able to antagonise the antinociceptive effect of morphine against formic acid-induced writhing, did not reverse the antinociceptive effects of THC. There were no pharmacological interactions between THC, CBD and CBN.

MeSH terms

  • Abdominal Muscles / drug effects
  • Analgesics*
  • Animals
  • Cannabinoids / pharmacology*
  • Dronabinol / pharmacology
  • Drug Interactions
  • Formates / pharmacology
  • In Vitro Techniques
  • Male
  • Mice
  • Muscle Contraction / drug effects*
  • Naloxone / pharmacology
  • Prostaglandins E / pharmacology

Substances

  • Analgesics
  • Cannabinoids
  • Formates
  • Prostaglandins E
  • Naloxone
  • Dronabinol